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dc.contributor.authorRodríguez-Romaguera, José
dc.contributor.authorSotres-Bayón, Francisco
dc.contributor.authorQuirk, Gregory J.
dc.contributor.authorMueller, Devin
dc.date.accessioned2017-05-16T19:08:22Z
dc.date.available2017-05-16T19:08:22Z
dc.date.issued2009-05
dc.identifierBiological Psychiatry, 65 (10): 887–92.en
dc.identifier.citationRodríguez-Romaguera, J., Sotres-Bayón, F., Mueller, D., Quirk, G.J. (2009) Systemic propranolol acts centrally to reduce expression of cued fear in rats without impairing extinction learning. Biological Psychiatry 65:887-892.en
dc.identifier.issn0006-3223
dc.identifier.urihttp://hdl.handle.net/11721/1590
dc.description.abstractBackground—Previous work has implicated noradrenergic beta-receptors in the consolidation andreconsolidation of conditioned fear. Less is known, however, about their role in fear expression and extinction. The beta-receptor blocker propranolol has been used clinically to reduce anxiety. Usingan auditory fear conditioning task in rats, we assessed the effects of propranolol on the expression and extinction of also assessed.en_US
dc.description.abstractMethods—One day after receiving auditory fear conditioning, rats were injected with saline, propranolol or peripheral blocker sotalol (both 10 mg/kg, ip). Twenty minutes after injection, rats were given either 6 or 12 extinction trials and were tested for extinction retention the following day. The effect of propranolol on the firing rate of neurons in prelimbic (PL) prefrontal cortex was also assessed.en
dc.description.abstractResults—Propranolol reduced freezing by more than 50%, an effect that was evident from the first extinction trial. Suppression was also significantly reduced. Despite this, propranolol had no effect on the acquisition or retention of extinction. Unlike propranolol, the peripheral blocker sotalol did not affect fear expression, although both drugs significantly reduced heart rate. This suggests that propranolol acts centrally to reduce fear. Consistent with this, propranolol reduced the firing rate of PL neurons.en
dc.description.abstractConclusion—Propranolol reduced the expression of conditioned fear, without interfering with extinction learning. Reduced fear with intact extinction suggests a possible use for propranolol in reducing anxiety during extinction-based exposure therapies, without interfering with long-term clinical response.en
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectNoradrenergicen_US
dc.subjectHeart rateen_US
dc.subjectPrelimbicen_US
dc.subjectPrefrontalen_US
dc.subjectPTSDen_US
dc.subjectAnxiety disorderen_US
dc.subject.meshConditioning, Classical/drug effectsen
dc.subject.meshConditioning, Operant/drug effectsen
dc.subject.meshExtinction, Psychological/drug effectsen
dc.subject.meshFear/drug effectsen
dc.subject.meshPrefrontal Cortex/drug effectsen
dc.subject.meshPropranolol/pharmacology*en
dc.subject.meshPropranololen
dc.subject.meshSotalolen
dc.titleSystemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinctionen_US
dc.typeArticleen_US
dc.description.FacultySchool of Medicineen_US
dc.description.DepartmentDepartment of Anatomy and Neurosciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.biopsych.2009.01.009


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