Now showing items 1-5 of 5
Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis
(Nature Publishing Group, 2016-01-14)
In endometriosis, the increased survival potential of shed endometrial cells (which normally undergo anoikis) is suggested to promote lesion development. One mechanism that may alter anoikis is autophagy. Using an autophagic ...
Early-onset of sporadic basal-cell carcinoma: Germline mutations in the TP53, PTCH, and XPD genes
(University of Puerto Rico Medical Sciences Campus, 2007-12)
Background: Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer in the Western world. The objective of this study was to examine together germline mutations in the TP53, PTCH, and XPD genes as risk ...
Patients’ report on how endometriosis affects health, work, and daily life
The objective of this study was to assess the burden of endometriosis by obtaining Patient Reported Outcome (PRO) data describing the experience of living with this disease. Survey data from one hundred and seven women ...
SNPs in the lysyl oxidase-like protein 4 (LOXL4) and complement component 3 (C3) genes are associated with increased risk for endometriosis and endometriosis-associated Infertility
This study was conducted to assess genetic associations to endometriosis in a Puerto Rican population. Significant differences in allelic frequencies and genotype distribution of genetic variants in LOXL4 and C3 were ...
Basal and steroid hormone-regulated expression of CXCR4 in human endometrium and endometriosis
(SAGE Publications, 2010-10)
Endometriosis is associated with activation of local and systemic inflammatory mechanisms, including increased levels of chemokines and other proinflammatory cytokines. We have previously reported increased gene expression ...