Now showing items 1-10 of 11
Cardiac and renal effects of atrasentan in combination with enalapril and paricalcitol in uremic rats
(Karger Publishers Open Access, 2014-09)
Background/aims: The search for new therapies providing cardiorenal protection in chronic kidney disease (CKD) has led to treatments that combine conventional renin-angiotensin-aldosterone-system inhibitors with other drugs ...
Importance of vitamin D and vitamin D levels status in Puerto Ricans
(Johns Hopkins University Press, 2013-11)
There is growing and compelling evidence demonstrating the extra-skeletal role of vitamin D and the importance of maintaining adequate levels of this nutrient. Currently, there is very limited information available on the ...
Allelic frequency of PAR-2 in the Puerto Rican population a possible insight to asthma prevalence.
(University of Puerto Rico at Ponce, 2007)
The Human Genome Project has sequenced the genetic complement of our species: the DNA. Such sequencing was performed using DNA randomly collected from individuals of diverse ethnicity backgrounds. This aleatory selection ...
Human immunodeficiency virus nef signature sequences are associated with pulmonary hypertension
(Mary Ann Liebert, 2012-06)
Severe pulmonary hypertension (PH) associated with vascular remodeling is a long-term complication of HIV infection (HIV-PH) affecting 1/200 infected individuals vs. 1/200,000 frequency in the uninfected population. Factors ...
Effects of antioxidant n-acetylcysteine against paraquat 1-induced oxidative stress tissues of mice.
(International Journal of Sciences: Basic and Applied Research (IJSBAR), 2016)
Paraquat (PQ) is a commonly used herbicide that induces oxidative stress via reactive oxygen species (ROS) generation. This study aimed to investigate the effects of the antioxidant N-acetylcysteine (NAC) against PQ-induced ...
Effect of paricalcitol and enalapril on renal inflammation/oxidative stress in atherosclerosis
(Baishideng Publishing Group, 2015-08-26)
AIM: To investigate the protective effect of paricalcitol and enalapril on renal inflammation and oxidative stress in ApoE-knock out mice.
Evaluation of extraction methods for the isolation of dust mites, bacterial, and fungal PCR-quality DNA from indoor environmental dust samples: A new scope for indoors research
(Chartered Institute of Environmental Health, 2006)
Dust mites, bacteria, and fungi are ubiquitous organisms found in household dust and have been related to the development of three types of human diseases: hypersensitivity responses (allergic reactions), infections, and ...
Early-onset of sporadic basal-cell carcinoma: Germline mutations in the TP53, PTCH, and XPD genes
(University of Puerto Rico Medical Sciences Campus, 2007-12)
Background: Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer in the Western world. The objective of this study was to examine together germline mutations in the TP53, PTCH, and XPD genes as risk ...
Adiponectin expression and the cardioprotective role of the vitamin D receptor activator paricalcitol and the angiotensin converting enzyme inhibitor enalapril in ApoE-deficient mice
(SAGE Publications Open Access, 2014-12)
Background—Coronary heart disease (CHD) is the number one cause of death in the US. The adipokine adiponectin has been studied intensively for presenting and inversed association with almost every stage of CHD. For instance, ...
Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys
While the mechanisms of cellular aging remain controversial, a leading hypothesis is that mitochondrial oxidative stress and mitochondrial dysfunction play a critical role in this process. Here, we provide data in aging ...